Abstract: [Abstract] Objective To observe clinical significance and variation of plasma B-type natriuretic peptide(△BNP) levels before and after treadmill exercise test(TET) in women with coronary heart disease． Methods Selected cases of women with suspected coronary heart disease in 61 cases(except for heart failure, blood BNP levels were normal)，all patients underwent coronary angiography，were divided into 25 cases of normal group and 36 cases of coronary heart disease group. All patients underwent TET were measured plasma BNP levels before and after the test，compared levels of plasma BNP before and after TET in both groups after one week．The levels of △BNP before and after DSE in different degree of coronary artery lesions patients were compared. The diagnostic value of the levels of △BNP in coronary heart disease was evaluated by the receiver operating characteristic curve (ROC). Results The levels of plasma BNP after TET in coronary heart disease group increased significantly(P <0.01) than before the test. The levels of △BNP before and after TET in different degree of coronary lesions patients was statistically significant difference, multivessel disease group was higher than that of single and double operation lesion group (P < 0.05), double vessel disease group was higher than that of single vessel disease group (P < 0.05). When the levels of △BNP > 7.3 pg/ml, the sensibility value and specificity value of diagnosing CHD was 82.4% and 81.5%. Area under curve(AUC) was 0.900, and 95% confidence interval was 0.796-0.962. Conclusion Detection of the levels of △BNP before and after TET in women with coronary heart disease patients with diagnosis and evaluation has important clinical significance.

Key words: B-type natriuretic peptide, treadmill exercise test, women, coronary heart disease, coronary angiography