Abstract: 　　　　　　【Abstract】 Objective to observe the application of local anesthesia with midazolam and sufentanil for patients in ophthalmologic plastic surgery. Methods The 160 patients (ASAⅠ~Ⅱ) were randomly divided into two group through the random number table,80 cases in each group. groupⅠ:local anesthesia; groupⅡ;local anesthesia with midazolam(0.05mg/kg) and sufentanil(0.1μg/kg) .Record the bispectral index(BIS),systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),respiratory rate(RR),oxyhemoglobin saturation（SpO2）,visual analogue scale(VAS) at into the operating room,during injection of local anesthesia, at the beginning of the procedure ,20min after the beginning of the procedure and after operation.Record the hypoxemia, apnoea, restlessness, nausea and vomiting and the time of operation. Results The age, gender, weight and operation time in two groups is not difference (P＞0.05). In groupⅠ, The BIS value is not significant difference in all the time(P＞0.05) . In group Ⅱ, compared with before anesthesia induction,The BIS value was significantly decreased during injection of local anesthesia, at the beginning of the procedure and 20min after the beginning of the procedure (P＜0.05). Compared with into the operating room the SBP,DBP and HR were significantly increased during injection of local anesthesia, at the beginning of the procedure, 20min after the beginning of the procedure and after the procedure, RR was increased during injection of local anesthesia, at the beginning of the procedure and 20min after the beginning of the procedure in groupⅠ(P＜0.05). Compared with before anesthesia induction the SBP, DBP, HR and RR was decreased in group Ⅱ(P＜0.05). During local anesthesia injection and procedure time ,the VAS in groupⅠis higher than groupⅡ(P＜0.05). Restlessness in 15 cases In groupⅠ was higher than 3 cases in groupⅡ. In groupⅡ nausea in 3 cases, anoxemia in 3 cases, no apnea . Conclusion consious sedation with midazolam and sufentanil is an effective anesthetic technique for patients in ophthalmologic plastic surgery.

Key words: Local anesthesia, Midazolam, Sufentanil, Sedation and analgesia, Ophthalmologic plastic surgery