Abstract:

[Abstract] Objective Todiscuss the correlation between C- peptide level and autonomic neuropathy in diabetic foot in patients with type 2diabetes mellitus (T2DM).Methods The levels of fasting blood glucose (FBG),2h postprandial blood glucose (2h-PG) and fasting C-peptide (FC-P) were detected in124T2DM patients. The Neuropad was used to test functions of sudomotor nerves in foot. Patients were divided into two groups: diabetic autonomic neuropathy (DAN) group and non-autonomic neuropathy group (NDAN) according to the results of functions of sudomotor nerves in foot. Values of gender, age, body mass index (BMI), blood pressure, FBG,2h-PG and FC-P were compared between the two groups. The Pearson correlation analysis was carried out between the indexes mentioned above and the time for completing color change of Neuro? pad.Results There were no significant differences in gender, age, FBG and2h-PG between two groups (P>0.05). The FC- P level was (1.07±0.75)nmol/L in DAN group, which was significantly lower than that in NDAN group (1.43±1.00) nmol/L (P>0.05). The time for completing color change of Neuropad was negatively correlated with C- peptide. Conclu? sion Theautonomic nerve functions in diabetic foot is closely related with C-peptide. It is inferred that C-peptide may have protective effect on autonomic nerves in diabetic foot.

Key words: C-peptide, Type 2 diabetes, Autonomic neuropathy, Neuropad