Tianjin Medical Journal

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Research Progress on the Relationship between Metabolic Syndrome and

Yao TIAN1,WANG Yi 2,ZHU Keyun 2,WANG Baichuan 2,CAO Xuchen 3   

  1. 1. Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Medical UniversityTianjin 300060, China
    2. Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Medical University,Tianjin 300060, China
    3. Corresponding Author E-mail：cxc@medmail.com.cn
  • Received:2014-05-27 Revised:2014-06-28 Published:2014-09-15 Online:2014-09-15
  • Contact: Yao TIAN

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Abstract: 【Abstract】Metabolic syndrome (MS) and breast cancer are common diseases of women. Triple negative breast cancer (TNBCs) is one type of breast cancer which is of much attention in recent years. Important components of MS include central obesity, high blood sugar, high triglycerides and low high-density lipoprotein (HDL-C) increased the incidence risk of TNBCs. Common biomarkers of MS which are insulin, adiponectin and leptin play an important role in the occurrence and development of breast cancer especially TNBCs. Insulin-like growth factor-IImRNA binding protein 3 (IMP3, an oncofetal protein) may be TNBCs’ new invasive cancer biomarkers. In this paper, the progress of research on the relationship between MS and TNBCs will be reviewed.

Key words: metabolic syndrome X, breast neoplasms, insulin, leptin, adiponectin, review, triple-negative breast cancers