Abstract: Abstract： The key treatment for overlap syndrome should focus on maximizing the therapeutic effect of each condition and concentrate of interventions that have showed benefit in both diseases. The goal of therapy includes the improvement in objective data including the reduction in sleep fragmentation, exacerbation rate, hospitalization frequency and mortality, and subjective data such as daytime functioning, quality of life and sleep quality. At present, the treatment of overlap syndrome is mainly rely on the positive airway pressure to improve ventilatory capacity and gas exchange function. Oxygen therapy as auxiliary treatment can alleviate hypoxemia. The key of drug therapy is to dilate the bronchus, clear secretions, reduce in⁃ flammatory response to improve the ventilation function. Meanwhile, daily exercise and dietary habits of life activity are indis⁃ pensable in the treatment of the disease as important supporting role to improve the motor function and the quality of life in patients.

Key words: pulmonary disease, chronic obstructive； sleep apnea, obstructive； continuous positive airway pressure； over? lap syndrome, oxygen therapy