Abstract:

Abstract： Objective To explore the value of combined detection of parathyroid hormone（PTH） , β2-microglobulin （β2-
MG）and high sensitivity C-reactive protein（hs-CRP） in differentiating diagnosis of acute and chronic renal failure. Meth⁃
ods Patients diagnosed with renal failure was divided into acute renal failure patients group (n=64) and chronic renal fail⁃
ure group (n=74) . Other patients with non-renal failure kidney disease (NRF group, n=80) and healthy adult (control group,
n=80) were also selected. Levels of PTH, β2-MG, hs-CRP , PTH+β2-MG, PTH+hs-CRP, β2-MG+ hs-CRP and PTH+β2-
MG+ hs-CRP were compared between these four groups to choose the optimal combination for differential diagnosis. Re⁃
sults Hs- CRP in ARF group was significantly higher than that in control group and CRF group. Levels of PTH and β2-
MG were significantly lower in ARF group than that in CRF groups but not in control group (P < 0.01). hs- CRP and β2-
MG in the ARF group were moderately higher (68.7%) and severely higher (81.2%) while PTH was mild higher (25%) in
ARF group than those in control group, On the other hand, hs-CRP and β2-MG in the ARF group were moderately higher
(56.8%) and severely higher (98.6%) while PTH was mild higher (39.2%) in ARF group than those in control group. Combina⁃
tion of hs-CRP with β2-MG could increase total case rate (TCR) and Youden index (YI) of ARF; while combination of PTH
and β2-MG could improve the TCR and YI of CRF. Conclusion Combined detection of PTH, β2-MG and hs-CRP is use⁃
ful in differential diagnosis of ARF and CRF.

Key words: parathyroid hormone, β2-microglobulin, high sensitivity C-reactive protein, renal failure, differential diagnosis