Abstract: Objective To explore correlation of Xinjiang Kazakh population who suffered from COPD with polymor⁃ phisms of F+1,S2,T1,ST+5 locus of ADAM33 gene. Methods Blood samples (n=193) from healthy controls (Control group, n=193) and COPD patients (Case group, n=197) were detected by SNP SNaP shot. Results Comparing case group with the control group, gene frequency and allele frequency of F+1 locus were of significant differences (P < 0.05). In patient group, there were no significant differences in F+1 locus genotype and in clinical indicators include lung function FEV1 predicted and FEV1/FVC (P > 0.05). The gene frequencies and allele frequency of S2、T1 and ST+5 locus were not significantly differ⁃ ent between case group and control group (P > 0.05). F+1 and S2 locus were analyzed by haplotype analysis which showed that there was significant differences in Hap1 (CC) haplotype between case group and control group (P < 0.05), and OR < 1 indicated that its haplotype may reduce the risk of COPD . There were significant differences (P < 0.05) in Hap3(TC) haplo⁃ type between case group and control group and OR > 1 revealed that its haplotype may increase the risk of COPD . The distri⁃ bution of Hap2 (TG) and Hap4 (CG) were not significantly different (P > 0.05) between the 2 groups. T1 and ST+5 locus were analyzed by haplotype analysis which showed significant differences in haplotypes between case group and control group (P < 0.05). Conclusion The occurrence of COPD may be related to the polymorphism of ADAM33 gene in F+1 locus in Xinjiang Kazakh.

Key words: pulmonary disease, chronic obstructive, ADAM proteins, polymorphism, single nucleotide, KAZAKH NATIONALITY, ADAM33 gene, haplotype