Tianjin Medical Journal

Tianjin Med J ›› 2015, Vol. 43 ›› Issue (12): 1433-1436.doi: 10.11958/j.issn.0253-9896.2015.12.023

• Clinical Study • Previous Articles     Next Articles

A prospective study of the relationship between alcohol consumption and outcome of three-year pre-diabetes

CHE Xiaoli1,2，WAN Qin1△   

  1. 1 Department of Endocrinology, the Affiliated Hospital of Luzhou Medical College，Luzhou，Sichuan 646000，China； 2 Department of Endocrinology, the Second People′s Hospital of Neijiang
  • Received:2015-04-01 Revised:2015-06-28 Published:2015-12-15 Online:2015-12-11
  • Contact: △Corresponding Author E-mail：wanqin3@163.com E-mail:cxli336699@163.com

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Abstract: Objective To investigate the associations of alcohol consumption with the outcome of three-year pre-dia⁃ betes. Methods The objects of this study were selected from the epidemiological study of cancer risk of Chinese patients with type 2 diabetes mellitus (T2DM) in Luzhou area. A total of 1 125 cases with pre-diabetes were selected from the base⁃ line survey. Patients divided into four groups including non-alcohol drinking group, small alcohol drinking group, moderate alcohol drinking group, and large alcohol drinking group. Patients also were divided into two groups according to body mass index (BMI, more than 24 kg/m2). The patients were followed up for three years. The incidence rates of diabetes mellitus were compared between different drinking groups and different BMI groups. Results A total of 1 116 cases were completed the follow-up , 9 cases were lost to follow-up. The incidence rates of DM were 18.81%, 8.80%, 16.51% and 26.53% for non-al⁃ cohol drinking group, small alcohol drinking group, moderate alcohol drinking group, and large alcohol drinking group. Cox proportional hazard regression analysis showed that the relative risk ratios and 95%CI of the gender, age, BMI, calorie, base⁃ line blood glucose were 0.49 (0.31-0.79), 1.15 (0.69-1.92) and 1.95 (1.25-3.04) for small alcohol drinking group, moderate alcohol drinking group, and large alcohol drinking group. In the group of BMI < 24 kg/m2，the relative risks and 95%CI were 0.40 (0.20-0.80)，0.77 (0.30-1.97) and 1.10 (0.46-2.64) for small alcohol drinking group, moderate alcohol drinking group, and large alcohol drinking group. In the group of BMI≥24 kg/m2, the relative risks and 95%CI were 0.62 (0.33-1.66)，1.49 (0.80-2.80) and 2.64 (1.55-4.47). Conclusion Small amount of alcohol drinking can reduce the incidence of DM in predia⁃ betes people with BMI<24 kg/m2. Large amount of alcohol drinking is the risk factor of incidence of DM in people with BMI≥ 24 kg/m2.

Key words: alcohol drinking, prediabetic state, incidence, prospective studies, follow-up studies