Tianjin Medical Journal ›› 2015, Vol. 43 ›› Issue (7): 756-760.doi: 10.11958/j.issn.0253-9896.2015.07.015
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ZHANG Shujian, ZHANG Hui, ZHAN Jianghua
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ZHANG Shujian, ZHANG Hui, ZHAN Jianghua. The role of RET proto-oncogene methylation in the pathogenesis of Hirschsprung's disease[J]. Tianjin Medical Journal, 2015, 43(7): 756-760.
Abstract: Abstract: Objective To investigate the relationship between the methylation of RET (proto-oncogene, RET) and Hirschsprung disease (HD), and understand its significance in the development of intestinal wall ganglion cells. Methods Twenty-one surgical removal specimens, which were all dilation segment of HD in Tianjin Children’ s Hospital, were used as experimental group, and 5 samples of non-HD normal colon tissues were used as control group. The bisulfite sequencing (BSP) - direct detecting method was used to detect RET CpG island methylation status. The expression of RET protein was
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URL: https://www.tjyybjb.ac.cn/EN/10.11958/j.issn.0253-9896.2015.07.015
https://www.tjyybjb.ac.cn/EN/Y2015/V43/I7/756
