Abstract: Spontaneous intracerebral hemorrhage (SICH) refers the primary, non-traumatic parenchymal hemorrhage.In China, SICH accounts for about 20%-30% of total strokes. SICH is a kind of disease affected by multiple factors includ⁃ing environmental and genetic factors. The high morbidity and mortality cause serious damage to human health. Therefore, it is important to find etiology and risk factors of SICH. The article reviewed the progress of SICH pathogenesis in the perspec⁃ tive of genetics and molecular biology.

Key words: cerebral hemorrhage, genetic polymorphism, pathogenesis, smolecular mechanisms, genetic factors, review