Abstract: Abstract: Brain injury is a major cause of worldwide mortality and disability, and it has brought a heavy burden to the society and the family. The hypothermia of brain injury animal models can provide new intervention and therapeutic measures for the brain injury patients. The role of brain protection has been demonstrated in a large number of animal models of brain injury in mild hypothermia experiments. However, the pattern of mild hypothermia in brain injury animals, at present, is not fully delineated, and the optimal pattern, such as the duration, induced method and the topgallant temperature is still unclear. Therefore, this paper summarizes the experimental method of mild hypothermia in brain injury animal model.

Key words: mild hypothermia, brain injury, animal model, treatment pattern