Abstract: Abstract: Objective To investigate the short term result of Toric orthokeratology (ortho-k) in correcting myopic teenagers with moderate to high astigmatism. Methods A total of 30 patients (58 eyes) who were treated in our hospital were included in this study. All patients met the inclusion criteria, and their average age were 10.62 yrs (8-14 years old), with myopia of (-0.75)-(-5.00) D and astigmatism of (-1.50)-(-3.00) D. All of the patients were fitted with Toric ortho-k. The patients were followed up for 1 day, 1 week, 1 month and 3 months since commencement of lens wear, and then they were examined for uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), refractive error, corneal curvature and corneal topography. Results The success rate of first lens fitting was 96.55%. The myopia, astigmatism and uncorrected visual acuity were changed significantly（P＜0.05） in 1day, 1 week， 1 month and 3 months compared with the baseline. After 3-month lens wearing, the myopia decreased by an average of (3.74 ± 0.88) D, reduced 98.7%; and the astigmatism decreased by an average of (1.68±0.55) D, achieved 80.8% reduction. The uncorrected visual acuity was up to the best corrected visual acuity before wearing the lens, the difference showed no statistically significant. Moreover, there were significant differences in flat K， steep K and cylinder of corneal topography at each time point (P＜0.05). Besides, the surface regular index and surface asymmetry index of corneal topography failed to show the significant difference. Finally, no significant corneal pigment ring, corneal microcapsule edema, corneal epithelial exfoliation and corneal infection, or other adverse events were observed during lens wearing. Conclusion Toric orthokeratology is a safe and effective correction treatment for myopic teenagers with moderate to high astigmatism.

Key words: myopia, astigmatism, adolescent, orthokeratology, Toric design