Abstract: Abstract: Tumor and bacterial infections are seriously endanger human health. Therefore, it is urgent to develop effective theranostic methods to overcome these two types of diseases. In-situ self-assembling peptides can target to in-situ aggregation of lesions induced by certain specifically high-expressed substances at the lesion site and form stable nanostructures through self-assembly, thereby facilitating the accurate diagnosis and effective therapy of diseases. The therapeutic effect and the reduced toxic side effects on normal tissues make the in-situ self-assembling peptides a kind of medical material with broad application prospects in the diagnosis and treatment of diseases. This article reviews the research progress of in situ self-assembling peptides in the diagnosis and treatment of tumor and bacterial infections.

Key words: neoplasms, bacterial infections, diagnosis, therapy, in situ self-assembling peptide, theranostic