Abstract: Objective To investigate short-term efficacy and safety of bronchoscope implantation radioactive 125I particle in the treatment of central type lung cancer with atelectasis. Methods Bronchoscopy implantation radioactivity 125I particles were used for treatment of 21 patients with central lung cancer. The puncture points were selected at 12：00, 3：00,6：00, 9：00 on the center of the tumor surface. After penetrating into the lesions, each particle distance was kept about 0.5cm, and 6-10 particles were implanted. The cough and gasp index were observed in patients after 2 weeks of surgery. The bronchial lumen dilatation variety was observed by bronchoscopy 1 month after surgery. The chest CT was re-checked to review the situation of atelectasis. Results The cough and gasp index were reduced 2 weeks after surgery (P＜0.01).Compared with preoperation, 18 cases showed bronchial lumen enlarged and 6 cases showed the lumen new biological mass disappeared completely after operation. The chest CT scan one month after surgery showed that atelectasis re-expansion completely in 13 cases, partial re-expansion in 8 cases. All of patients were followed up for 6 to 24 months, and the median survival was 12 months with less complications. Conclusion The bronchoscope implantation radioactive 125I particles are effective and safe for treatment of central type lung cancer with atelectasis.

Key words: bronchoscopy, lung cancer, atelectasis, iodine radioisotopes