Abstract: Abstract: Objective To study the relationship between the waist circumference phenotype of hypertriglyceridemic(TG) and the risk of prediabetes and type 2 diabetes mellitus (T2DM). Methods A total of 1 722 subjects with normal glucose tolerance were recruited from the epidemiological study of cancer risk of T2DM in Luzhou area in 2011. Based on the cut-point of triglyceride (TG) level≥1.7 mmol/L and waist circumference (WC) ≥ 90 cm for men and 80 cm for women, the subjects were divided into four groups: normal WC and normal TG level group (n=856), simple high TG level group (n=133),simple abdominal obesity group (n=518), and enlarged WC and high TG level (HTWC) group (n=215). The subjects were followed up for five years, and the incidence rates of prediabetes and T2DM were compared between four groups. Results After five-year follow up, in the 1 722 subjects with normal glucose tolerance, 445 developed prediabetes and 67 developed T2DM. The incidence rates of prediabetes were 20.7 (177/856), 21.1% (28/133), 30.5% (158/518) and 38.1% (82/215), and the incidence rates of T2DM were 2.9% (25/856), 3.8% (5/133), 4.4% (23/518) and 6.5% (14/215) for normal WC and normal TG level group, simple high TG level group, simple abdominal obesity group and HTWC group. After adjusting age, gender, fasting glucose, 2 h postprandial blood glucose, systolic pressure and glycated hemoglobin, subjects with the hypertriglyceridemic waist (HTGW) phenotype showed higher odds of prediabetes (OR=1.961, 95%CI: 1.387-2.773) and T2DM (OR=2.638, 95%CI: 1.279-5.441) compared to normal group. Conclusion HTGW phenotype is the risk factor of prediabetes and T2DM. It can serve as a simple tool to identify individuals at high risk of prediabetes and T2DM.

Key words: triglycerides, prediabetic state, diabetes mellitus, type 2;, epidemiologic studies, hypertriglyceridemicwaist phenotype