Abstract: Objective To investigate the correlation between the serum level of growth arrest-specific protein 6 (GAS6) and other inflammatory factors in patients with severe preeclampsia. Methods A total of 133 cases of pregnant women hospitalized in our hospital were retrospectively chosen from January to October of 2018. Patients were divided into two groups. The case group included 77 cases of patients with severe preeclampsia. The control group included 56 healthy pregnant women. The serum levels of GAS6, interleukin 6 (IL-6), IL-10 and IL-18 were measured by enzyme-linked immune sorbent assay. C reactive protein (CRP) was measured by biochemical analyzer. The correlation of the above indexes were analyzed in two groups of patients. Results The systolic blood pressure and diastolic blood pressure were higher in the severe preeclampsia group than those of the control group, and the gestational age was less in the severe preeclampsia group than that of the control group. The serum levels of GAS6 and IL-10 were significantly lower in the severe preeclampsia group than those in the control group (P＜0.05), while the levels of IL-6 and IL-18 were higher than those in the control group (P＜0 05). The serum GAS6 level was negatively correlated with IL-6. Conclusion In severe preeclampsia patients, the serum GAS6 is involved in inflammatory reaction and plays the role of anti-inflammatory factors. The serum level of GAS6 is related with the severity of inflammatory reaction.

Key words: pregnancy, interleukin-6, interleukin-10, interleukin-18, severe pre-eclampsia, growth arrest specific gene product 6