Abstract: Abstract: Objective To explore the correlation between triglyceride glucose (TyG) index with coronary artery disease (CAD) and coronary artery calcified plaque burden. Methods A total of 620 inpatients with suspected stable CAD were consecutively enrolled from September 2015 to June 2017 in the Affiliated Hospital of Chengde Medical College. Patients were divided into CAD group (n=449) and non-CAD group (n=171) according to coronary computed tomographic angiography (CCTA) results. The clinical data and coronary artery calcification score (CACS) of all patients were collected. A binary Logistic regression model was established on the risk factors of CAD and CAC. Results The prevalence of CAD, type 2 diabetes, dyslipidemia and CAC were higher in the high TyG index group than those in the low TyG index group (all P＜0.05). TyG index was positively correlated with CACS and classical risk factors of CAD including epicardial adipose tissue enlargement, pericardial adipose tissue enlargement and body mass index, while negatively correlated with serum magnesium (all P＜0.05). Conclusion High TyG index is associated with coronary atherosclerosis plaque burden and CAD. The increased TyG index is an independent risk factor for CAD and CAC.

Key words: coronary artery disease, vascular calcification, plaque, atherosclerotic, risk factor, triglyceride glucose