Abstract: Cholangitis is among the most common complication after Kasai procedure in children with biliary atresia, which has great impact on the quality of life and native liver survival of children. The liver condition during Kasai operation can affect the postoperative bile drainage. The incidence of cholangitis after Kasai operation is associated with bile drainage. The proliferation of bacteria within the bile conduit of jejunum due to the change of intestinal environment maybe the main cause of cholangitis. Intestinal content reflux after Kasai operation may also induce the occurrence of cholangitis. In addition to the direct retrograde infection, enteric bacteria can also break through the intestinal mucosa and enter the liver through the portal vein to induce cholangitis.