Abstract: Abstract: Metabolomics is sensitive, fast, and high-throughput. It has application potential in studying the changing laws of endogenous small molecules, discovering abnormal metabolites, and revealing individual metabolic characteristics. Metabonomics has become a hot topic in the study of hyperuricemia combined with chronic kidney disease in recent years. Related metabonomics studies of hyperuricemia combined with chronic kidney disease show that the disease is closely related to the disorder of amino acid and lipid metabolism. This paper reviews the application of metabonomics in pathogenesis exploration, biomarker screening and Chinese herbal treatment of hyperuricemia combined with chronic kidney disease.

Key words: hyperuricemia, metabolomics, renal insufficiency, chronic, gas chromatography-mass spectrometry, lipid metabolism, DRUG THERAPY (TCD), amino acid metabolism