Tianjin Medical Journal

Tianjin Medical Journal ›› 2022, Vol. 50 ›› Issue (5): 493-497.doi: 10.11958/20212251

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Research on the correlation between neutrophil lymphocyte ratio, lymphocyte monocyte ratio and symptomatic intracranial atherosclerotic stenosis#br#

HU Mingzhe1, CHEN Xiangyan2, WU Guangliang3, QIAO Lijun3, CAI Yefeng3△   

  1. 1 Department of Neurology, Shandong Provincial Hospital of Traditional Chinese Medicine, Jinan 255014, China; 2 Department of Rehabilitation, Zibo City Hospital of Traditional Chinese Medicine; 3 Department of Neurology, Guangdong Hospital of Traditional Chinese Medicine
  • Received:2021-10-08 Revised:2022-01-13 Published:2022-05-15 Online:2022-07-04

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Abstract: Objective　To investigate the correlation between neutrophil lymphocyte ratio (NLR), lymphocyte monocyte ratio (LMR) and the pathogenesis of symptomatic intracranial atherosclerotic stenosis (sICAS). Methods　By retrospective analysis, a total of 649 sICAS patients were divided into the mild (58 cases), the moderate (202 cases) and the severe stenosis groups (389 cases) according to the severity of responsible artery stenosis. And the patients were divided into the mild neurological defect group (504 cases) and the moderate neurological defect groups (145 cases) according to the National Institutes of Health Stroke Scale score. Baseline data, laboratory and imaging outcomes were collected. Logistic regression analysis was used to investigate the independent risk factors affecting the degree of intracranial artery stenosis and neurological defect. Receiver operating characteristic curve (ROC) was used to explore the efficacy of NLR or LMR in detecting the degree of intracranial artery stenosis and neurological defects. Results　(1) Female (OR=3.132, 95%CI: 1.008-9.732), high NIHSS score at admission (OR=1.343, 95%CI: 1.020-1.769 ), high LDL-C (OR=7.341, 95%CI: 1.609-33.502) and high homocysteine (Hcy, OR=1.320, 95%CI: 1.069-1.630) were independent risk factors for the moderate intracranial arterial stenosis of sICAS. The high Hcy (OR=1.377, 95%CI:1.118-1.697) was an independent risk factor for severe intracranial arterial stenosis of sICAS. (2) The high Hcy (OR=1.106, 95%CI: 1.055-1.158) and high NLR (OR=1.612, 95%CI: 1.340-1.939) were independent risk factors for neurological defect of sICAS. (3) ROC curve indicated that NLR had a low predictive value for the degree of neurological defect in patients (95%CI: 0.567-0.668, P＜0.01) while LMR had no predictive value (95%CI: 0.465-0.573, P＞0.05). (3) When NLR was 3.5, the diagnostic efficiency was the highest. Conclusion　NLR is correlated with the degree of neurological defect of sICAS, and the increased NLR may be an independent risk factor for the aggravation of neurological defect. 

Key words: intracranial arteriosclerosis, symptomatic intracranial atherosclerotic stenosis, neutrophil lymphocyte ratio, lymphocyte monocyte ratio, neurological deficit

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