Abstract: Objective To investigate the safety and efficacy of photoselective greenlight vaporization of bladder tumor (PVBT). Methods A total of 522 patients of bladder cancer were enrolled in present study from January 2010 to May 2015, includ 405 cases of non muscle-invasive bladder cancer (NMIBC) and 117 cases of muscle-invasive bladder cancer(MIBC). They had been treated by PVBT with intravesical instillation of epirubicin and the patients in MIBC received intravenous chemotherapy (kisi-hama and cisplatin). Results All of the patients were treated by PVBT under spinal anesthesia or general anesthesia. The average hospitalization time of patients in NMIBC group was (7.32±1.28) days, the average operation time was (27.08±5.36) min, and the average time of indwelling urinary catheter was (2.42±0.34) days. During the follow-up period (12-60 months), 38 cases (9.4%) relapsed, of which 3 cases underwent radical cystectomy, and other 35 cases underwent PVBT again. All 405 patients were alive at the end of follow up. The average hospitalization time of MIBC patients was (26.18±1.92) days, the average operation time was (38.32±6.54) min, and the average time of indwelling urinary catheter was (2.72±0.85) days. During the follow-up period (12-60 months), 19 cases (16.2%) relapsed. Among them, 4 patients underwent radical cystectomy, and other 15 cases underwent PVBT. Six patients died from distant organ metastasis (including 2 cases of pulmonary metastasis and 4 cases of bone metastasis), and other 111 patients survived. Conclusion PVBT is safe and effective in the treatment of bladder tumor, especially for NMIBC and MIBC patients who are unable or unwilling to undergo radical cystectomy.

Key words: bladder tumor, urothelial carcinoma, laser therapy, greenlight vaporization, recurrence, follow up