Abstract: Objective To evaluate the effect of SvO2-guided early goal directed fluid therapy on hemodynamic and oxygen dynamics in septic shock pig model. Methods Twelve Bama miniature pigs (male, 21-24 kg) were equally randomized into 2 groups, group C and group G. Septic shock was induced by intravenous infusion endotoxin. Group C received hemodynamic support aiming central venous pressure at 8 to 12 mmHg, urinary output 0.5 mL/kg per hour, and mean arterial pressure greater than 65 mmHg. Group G maintained SvO2 greater than 0.65 in addition to the above indicators. The interventions lasted 6 h and at T0-T8 (0, 60, 120, 180, 240, 300, 360, 420 and 480 min) recorded temperature, hemodynamic and oxygen dynamics indexes for each group, and recorded 6 hours for accumulated liquid volume, vascular active drug, and changes of urine. Results There were no significant differences in mean arterial blood pressure (MAP), heart rate (HR) and systemic vascular resistance index (SVRI) at each time point between group G and group C (P＞0.05). Values of CI and CVP were increased at T4-T8 in group G (P＜0.05). Values of MPAP and PVRI were decreased at T8 in group G (P＜0.05). Values of SvO2 were increased at T3-T8, O2ER were decreased at T3-T8 (P＜0.05), DO2 were increased at T4-T8 (P＜0.05), Lac were decreased at T5-T8, and Δp(CO2) was decreased at T8 in group G (P＜0.05). There were no significant differences in values of VO2 at T1-T8 between two groups (P＞0.05). The amount of intravenous infusion and urine volume were more and the amount of norepinephrine was less in animals of group G (P＜0.05). The dosage of　dobutamine was more in animals of group G, and which was not used in animals of group C. Conclusion SvO2 guided fluid therapy is more effective than conventional treatment to stabilize hemodynamics and oxygen kinetics, which is characterized by the increased cardiac output, increased oxygen supply, normal oxygen uptake rate and good tissue perfusion.

Key words: disease models, animal, septic shock, hemodynamics, oxygen kinetics, SvO2, EGDT