Influence of low-frequency repetitive transcranial magnetic stimulation combined with brain-computer interface rehabilitation robot on stroke patients with upper limb motor dysfunction

doi:10.11958/20251930

Abstract

Abstract:

Objective To explore the influence of low-frequency repetitive transcranial magnetic stimulation (rTMS) combined with brain-computer interface rehabilitation robot in patients with upper limb motor dysfunction after stroke. Methods A total of 126 patients with upper limb motor dysfunction after stroke were divided into the combined group (61 cases, low-frequency rTMS combined with brain-computer interface rehabilitation robot on the basis of routine rehabilitation treatment) and the magnetic stimulation group (65 cases, low-frequency rTMS on the basis of routine rehabilitation treatment) according to different treatment methods, and both groups were continuously treated for 3 weeks. The upper limb motor function[upper-extremity Fugl-Meyer scale (UFMA), action research arm test (ARAT)], hand Brunnstrom staging, upper limb surface electromyography indicators [root mean square (RMS) and integrated electromyography (iEMG) of biceps brachii, triceps brachii, deltoid anterior bundle and deltoid middle bundle], cerebral artery hemodynamics [systolic blood flow velocity (Vs), resistance index (RI), mean blood flow velocity (Vm)] and ratio of fractional anisotropy (FA) of central region of brain lesion and FA of mirror-image region of healthy cerebral hemisphere (rFA) were observed before and after treatment in the two groups. Results Compared with the magnetic stimulation group, the UFMA score, ARAT score, hand Brunnstrom staging, Vs, Vm and rFA were higher after treatment in the combined group (P<0.05). The RMS and iEMG of biceps brachii, triceps brachii, deltoid anterior bundle and deltoid middle bundle were higher in the combined group compared with those of the magnetic stimulation group (P<0.05),while the RI was lower (P<0.05). Conclusion Combined treatment can more effectively improve the upper limb motor function of patients, enhance hand activity ability, promote the recovery of upper limb muscle and nerve function, and regulate the hemodynamics of cerebral arteries.

Key words: stroke, brain-computer interface robot, low-frequency repetitive transcranial magnetic stimulation, upper limb motor dysfunction, cerebral artery hemodynamics, surface electromyography

CLC Number:

R743.3

Figures/Tables 7

References 21

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组别		n	年龄/岁			性别（男/女）		病程/d
磁刺激组		65	56.12±12.08			45/20		60.85±12.18
联合组		61	54.97±9.12			37/24		58.30±14.80
t或χ²			0.609			1.018		1.059
组别	疾病类别			患侧		合并疾病
组别	脑出血		脑梗死	左侧	右侧	高血压	糖尿病	高脂血症
磁刺激组	16		49	19	46	30	26	12
联合组	21		40	25	36	32	23	15
χ²	1.460			1.913		0.501	0.070	0.702

组别		n	年龄/岁			性别（男/女）		病程/d
磁刺激组		65	56.12±12.08			45/20		60.85±12.18
联合组		61	54.97±9.12			37/24		58.30±14.80
t或χ²			0.609			1.018		1.059
组别	疾病类别			患侧		合并疾病
组别	脑出血		脑梗死	左侧	右侧	高血压	糖尿病	高脂血症
磁刺激组	16		49	19	46	30	26	12
联合组	21		40	25	36	32	23	15
χ²	1.460			1.913		0.501	0.070	0.702

组别	n	UFMA评分			ARAT评分
组别	n	治疗前	治疗后	t	治疗前	治疗后	t
磁刺激组	65	36.15±4.15	43.86±4.32	14.366^＊＊	28.49±3.44	35.65±3.43	17.981^＊＊
联合组	61	37.54±4.01	47.38±4.83	15.162^＊＊	28.11±3.45	39.11±4.48	16.324^＊＊
t		1.906	4.313^＊＊		0.615	4.860^＊＊

组别	n	UFMA评分			ARAT评分
组别	n	治疗前	治疗后	t	治疗前	治疗后	t
磁刺激组	65	36.15±4.15	43.86±4.32	14.366^＊＊	28.49±3.44	35.65±3.43	17.981^＊＊
联合组	61	37.54±4.01	47.38±4.83	15.162^＊＊	28.11±3.45	39.11±4.48	16.324^＊＊
t		1.906	4.313^＊＊		0.615	4.860^＊＊

组别	n	治疗前						治疗后						Z
组别	n	1期	2期	3期	4期	5期	6期	1期	2期	3期	4期	5期	6期	Z
磁刺激组	65	0	24	36	5	0	0	0	0	24	28	13	0	10.661^＊＊
联合组	61	0	21	34	5	1	0	0	0	9	28	19	5	12.218^＊＊
Z		0.414						3.262^＊＊