Tianjin Medical Journal

Tianjin Medical Journal ›› 2018, Vol. 46 ›› Issue (6): 657-660.doi: 10.11958/20180135

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Research progress of STIM1 in tumor development and clinical application

HU Jin-meng, WANG Jian   

  1. Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin Clinical Research Center for Cancer, Tianjin 300060, China
  • Received:2018-01-22 Revised:2018-03-22 Published:2018-06-15 Online:2018-07-05
  • Contact: HU JINMENG E-mail:hujinmeng11@sina.com

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Abstract: Studies have shown that stromal interaction molecule 1(STIM1) is closely related to the development of tumors, and which is involved in the regulation of apoptosis, proliferation, migration and invasion in many human cancers.Blocking or knockdown of STIM1 can significantly inhibit the proliferation and migration of cancer cells. Elucidation of the regulatory mechanism of STIM1 in cancer cells will be helpful for the identification of new therapeutic targets. This paper reviews the mechanism of STIM1 molecule in different tumors and its clinical application.

Key words: stromal interaction molecule1, calcium, store-operated calcium channels, store-operated calcium entry, Calcium release-activated calcium channels, Orai