Abstract: Objective To evaluate systematically the clinical efficacy and safety of stem cell therapies for patients with ischemic stroke. Methods PubMed, EMbase, the Cochrane Library, VIP database, Wanfang database and CNKI database were searched by computer about randomized controlled trials of stem cell therapies for patients with ischemic stroke. The retrieval time was from the set up of library to December 2018. Two systematic evaluators screened the literatures according to inclusion and exclusion standards, and extracted the important information of literature. After assessing the quality of included studies, the risk of bias was analyzed by Stata 11.0 software for systematic evaluation and forest plot analysis, and obtained the funnel plot and the sensitivity analysis of included studies. Results A total of 29 case-control studies including total of 1 908 ischemic stroke patients were included in the systematic screening. The results of Meta analysis showed that the neural function deficient degree score (NIHSS), Barthel index (BI), Fugl-Meyer assessment (FMA) and the functional independence measure (FIM) are significantly better in stroke patients with treatment of stem cell transplantation than those of patients in control group. Conclusion Stem cell transplantation can improve effectively the neurological deficit, autonomous behavior ability and body movement function of patients with ischemic stroke.

Key words: stem cells, transplantation, brain ischemia, stroke, randomized controlled trial, Meta-analysisanalysis