Abstract: Objective To understand the distribution characteristics and trends of multiple drug resistant organism (MDRO) in a new hospital, and to define the key point of MDRO prevention and control. Methods The target pathogen strains detected from inpatients in Zhengzhou Yihe hospital from July 2013 to June 2018 were collected, and the distribution and change trend of the isolated MDRO were analyzed. Results A total of 7 395 strains of targeted pathogens were detected, including 812 strains of MDRO. The majority of the isolated MDRO plants were carbapenems resistant acinetobacter baumannii (CR-AB, 185 plants, 22.78%), followed by carbapenems resistant Klebsiella pneumoniae (CR-KP,180 plants, 22.17%). The total detection rate of MDRO was 10.98% over the five-year, with an overall upward trend in the average annual detection rate (χ2=20.245, P < 0.001). The main type of MDRO infection was community infection (535 cases,65.89%), mainly concentrated in Neurosurgery, Critical Care, Neurology, and Respiratory Departments. Conclusion The prevention and control of multidrug resistant bacteria are gradually becoming more serious with the extension of the opening time in our hospital. Monitoring and management of CR-AB and CR-KP have become the focus of MDRO prevention and control.

Key words: drug resistance, bacterial, cross infection, infection control, multidrug-resisitance organism, surveillance