Abstract: Abstract: Objective To investigate the incidence and risk factors of contrast agent-induced acute kidney injury (CI AKI) in Uygur patients, and the role of RAAS inhibitors thereof. Methods Data of 218 Uygur patients underwent percutaneous coronary intervention (PCI) and detected renal function after 24-48 hours in the cardiac diagnosis and treatment center of People's Hospital of Hetian District, Xinjiang were retrospectively analyzed. Patients were divided into CI-AKI group (n=46) and the control group (n=172). Clinical data, risk factors and the role of RAAS inhibitors in CI-AKI were observed in two groups. Results In 218 patients, 46 (21.1%) were found CI-AKI. The prevalence of hypertension, dosage of contrast agent, LDL-C, NT-proBNP and hs-CRP levels were higher in CI-AKI group than those of the control group. RAAS inhibitor use ratio, LVEF, HDL-C and HB levels were lower in CI-AKI group than those in the control group. There was no significant difference in preoperative creatinine clearance between CI-AKI group and control group. The creatinine level before operation was lower in CI-AKI group than that in control group, but the level of creatinine increased significantly after operation in CI-AKI group (P＜0.05). There was no significant difference in the level of urea nitrogen before operation between the two groups, but the level of urea nitrogen increased significantly after operation in CI-AKI group (P＜0.05). Multivariate logistic analysis showed that the increased dosage of contrast agent, high NT-proBNP and hs- CRP levels were risk factors for CI-AKI in Uygur patients, and RAAS inhibitors were protective factors for reducing the occurrence of CI-AKI in Uygur patients. Conclusion For Uyghur patients undergoing PCI, preoperative use of RAAS inhibitor, improved the preoperative cardiac function and reduced intraoperative contrast agent dosage can reduce the incidence of CI-AKI

Key words: contrast media, kidney failure, acute, Uygur nationality, contrast agent-induced acute kidney injury, RAAS inhibitor