Abstract: Abstract: Objective To analyze the influencing factors of helicobacter pylori (HP) reinfection in patients with type 2 diabetes mellitus (T2DM) 48 weeks after a successful standard eradicating treatment. Methods A total of 179 T2DM patients from endocrine department of our hospital were included in our study. Among them 108 patients were evaluated HP infection by means of 13C-Urea Breath Test. All positive patients were eradicated by means of a standard quadruple therapy for 2 weeks. The eradication of HP was confirmed by means of 13C-Urea Breath Test performed at least four weeks after therapy, and 97 patients were successfully eradicated. After 48 weeks of follow-up, 97 patients underwent another 13C-Urea Breath Test. It was found that 74 out of 97 patients were negative and 23 positive for HP reinfection. The clinical data of 97 patients were collected and compared between two groups (HP negative group and HP positive group), including age, sex, body mass index (BMI), hemoglobin A1c (HbA1c), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), Uric acid (UA), the duration of diabetes mellitus (DM), insulin usage, socio-economic status (monthly income ≥ 3 000 yuan) and the history of smoking and drinking. The effects of these variables on HP reinfection were also evaluated. Results The prevalence of HP was 60.3% (108 / 179). The eradication rate of HP was 89.8% (97/108). The reinfection rate was 23.7% (23/97) after 48-week of follow-up. The duration of DM and the level of HbA1c were significantly higher, and the proportion of patients with monthly income ≥3 000 yuan was significantly lower in HP positive group than those of HP negative group (P＜0.05). There were no significant differences in other indexes between two groups (P＞0.05). Binary logistic regression analysis showed that the duration of DM (OR=1.195, 95%CI 1.049-1.136) and the level of HbA1c (OR=1.293, 95%CI 1.011~1.518) were risk factors of HP reinfection. Conclusion According to our data, there is HP reinfection in T2DM patients. The long duration of DM and high level of HbA1c are associated with HP reinfection.

Key words: helicobacter pylori, helicobacter infections, diabetes mellitus, type 2, hemoglobin A, glycosylated, risk factors