Abstract: Abstract: Objective To explore the association between the polymorphisms of fat mass and obesity associated gene (FTO) rs8050136 and the risk of polycystic ovary syndrome (PCOS). Methods Pubmed/MEDLINE, Embase, Web of Science, CNKI, Wanfang database, VIP Chinese Journal and CBM were searched. The searching time was from the establishment to November 11, 2019. According to the inclusion and exclusion criteria, case-control studies on the relationship between the FTO gene rs8050136 A/C polymorphism and PCOS were selected. The Rev-Man 5.2 and STATA 11.2 software were used for meta-analysis. Results Five case-control studies were included with a total of 2 750 patients, including 1 238 PCOS patients and 1 512 controls. Meta-analysis showed that the risk of PCOS in people with A allele was not higher than that in people with C allele (OR=1.19, 95% CI: 0.98-1.43, P=0.08). The risk of PCOS in people with AA genotype was 1.64 times higher than that in people with CC genotype (95% CI: 1.02-2.63, P=0.04) and the risk of PCOS in people with AC genotype was not higher than that in people with CC genotype (OR=1.20, 95% CI: 0.85-1.69, P=0.30). Conclusion rs8050136 polymorphism of FTO gene is associated with PCOS.

Key words: polycystic ovary syndrome, polymorphism, genetic, Meta-analysis, FTO gene