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Study on the levels of NLR and FIB and their correlation in patients with COPD and T2DM #br#
ZHAO Jian-mei, ZHANG Yan, LI Hui-fang, HE Qing△, SHAO Yan
2020, 48 (6):
547-551.
Abstract: Objective To investigate the relationship between neutrophil/lymphocyte ratio (NLR) and fibrinogen (FIB)
levels in patients with chronic obstructive pulmonary disease (COPD) and type II diabetes mellitus (T2DM). Methods The
clinical information of 120 patients who went to our hospital from July 2017 to January 2019 and met the inclusion criteria
was collected. According to the disease, patients were divided into three groups: group A (COPD patients without T2DM, n=
40), group B (patients with COPD and T2DM without microangiopathy, n=40) and group C (patients with COPD and T2DM
and with microangiopathy, n=40). The venous blood samples were drawn from patients, and the leukocytes, neutrophil and
lymphocyte counts were measured. The neutrophil/lymphocyte ratio (NLR) was calculated. The enzyme-linked
immunosorbent assay was used to detect FIB, triacylglycerol (TG), total cholesterol (TC), low density lipoprotein cholesterin
(LDL)-C, high density lipoprotein cholesterin (HDL)-C and high-sensitivity C-reactive protein (hs-CRP). The lung function
indexes were also measured. Results The years of smoking, the times of acute exacerbation of COPD and the proportion of
hypertension history were all higher in group B and group C than those in group A (P＜0.05). The levels of NLR and FIB
increased in turn in group B and group C, and there were significant differences between the groups (P＜0.05). In stable
COPD patients, T2DM was positively correlated with smoking years (r=0.125, P＜0.05), number of acute exacerbations of
COPD in one year (rs=0.151, P＜0.05), history of hypertension (rs=0.231, P＜0.05), NLR (rs=0.342, P＜0.05) and FIB (rs=
0.312, P＜0.05). Patients with stable COPD and T2DM, microvascular complications were positively correlated with smoking
years (rs=0.143, P＜0.05), prevalence of hypertension (rs=0.198, P＜0.05), NLR (rs=0.421, P＜0.05), and FIB (rs=0.350, P＜0.05). Multivariate Logistic regression analysis showed that the increased NLR (OR=1.644, 95%CI: 1.359-1.899) and FIB
(OR=1.647, 95%CI: 1.386-1.931) were independent risk factors for stable COPD combined with T2DM (P＜0.05). The
increased NLR (OR=1.731, 95%CI: 1.456-1.978) and FIB (OR=1.698, 95%CI: 1.543-1.928) were independent risk factors
for microvascular disease in stable COPD combined with T2DM (P＜0.05). Conclusion COPD combined with T2DM and
microvascular complications are closely related to NLR and FIB. NLR and FIB can be used as biomarkers for effectively
assessing the severity and prognosis of stable COPD combined with T2DM.
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