Abstract:  Objective To study the correlation between CA 19-9 levels and ovarian mature cystic teratoma systematically. Methods Data of the correlation between CA 19-9 and mature cystic teratoma were searched and collected from the database of Pubmed, CNKI, CBMdisc, and Wanfang. Two evaluators independently evaluated the quality of the literature and extracted the data. The literature will be grouped according to mature teratoma and immature teratoma, unilateral or bilateral lesions, with or without torsion, with or without neural tissue and thyroid tissue. Review Manager 5.3 was used for Meta-analysis. Results A total of 53 articles were included. The results were as follows: the concentration of CA 19-9 was lower in mature teratoma group (n=1 398) than that in immature teratoma group (n=145, P＜0.001). The concentration of CA 19-9 was higher in bilateral tumor group (n=614) than that in unilateral tumor group (n=3 126, P＜ 0.001). The concentration of CA 19-9 was higher in patients with tumor torsion group (n=18) than that in non-tumor torsion group (n=374, P＜0.001). There was no significant difference in the positive rate of CA 19-9 between the tumor group with nerve tissue (n=364) and the tumor group without nerve tissue (n=1 305, P=0.300). The positive rate of CA 19-9 was higher in the tumor tissue with thyroid tissue group (n=35) than that in tumor tissue without thyroid tissue group (n=1 135, P= 0.030). The positive rate of CA 19-9 decreased with the increase of age (r=- 0.818, P＜0.001) and increased with the increase of tumor size (r=0.927, P＜0.001). Conclusion There is a significant correlation between CA 19-9 concentration and MCT. There is higher concentration of CA 19-9 in the younger age group, which may indicate that the tumor is large, with the possibility of malignant, bilateral lesions, complications like tumor torsion, and the possibility of mixed thyroid tissue.

Key words: Meta-analysis, mature cystic teratoma, CA 19-9