Abstract: Post-translational modifications of proteins, as an important way to regulate protein function, are mainly catalyzed by enzymes that recognize specific target sequences in specific proteins. It affects different aspects of protein stability and activity, and is closely related to many important life activities. Irritable bowel syndrome (IBS) is a gastrointestinal dysfunction disorder, and its pathogenesis has not been fully clarified. Studies have shown that many post-translational modifications of proteins, such as acetylation, phosphorylation, methylation and glycosylation, play an important role in the development of IBS. This article summarizes several major protein modification types and their current research progress in IBS.

Key words: protein modification, translational, irritable bowel syndrome, acetylation, methylation, glycosylation, phosphorylation