Abstract: Objective To construct an individualized rehabilitation training intervention model based on comprehensive geriatric assessment (CGA) for patients with Alzheimer's disease (AD), and perform the effect analysis from the perspectives of cognitive function and risk prevention. Methods According to the prospective randomized controlled study, 220 patients with AD were selected as the research subjects. Patients were equally divided into control group (n=110) and observation group (n=110) by the random number table method. The control group was given conventional medication therapy and rehabilitation training, and the observation group was additionally given individualized rehabilitation training intervention based on CGA. Data of the cognitive function [Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), Mini-Mental State Examination (MMSE)], risk prevention [Johns Hopkins Fall Risk Assessment Tool (JHFRAT), Cohen-Mansfield Agitation Inventory (CMAI)], mood state [Profile of Mood States (POMS)], physical function [Berg Balance Scale (BBS) and Barthel index (BI)] before intervention and after 3-month intervention were compared between the two groups. Results After 3 months of intervention, the scores of ADAS-Cog scale, JHFRAT scale and CMAI scale were significantly reduced in observation group (P＜0.01), while the scores of MMSE scale and BBS scale were significantly increased (P＜0.01). There were no significant differences in the above indexes before and after intervention in control group (P＞0.05). After 3 months of intervention, the scores of activity-hyperactivity subscale of POMS scale and BI scale were significantly increased in the two groups of patients (P＜0.01), while the scores of subscales (tension-anxiety, melancholy-depression, anger-hostility, exhaustion-indolence, bewilderment-confusion) of POMS scale were significantly reduced (P＜0.01), and the changes were more significant in observation group (P＜0.01). Conclusion CGA-based individualized rehabilitation training intervention for patients with AD has a positive impact on cognitive function, fall risk, agitation behavior, mood state and physical function, which is worthy of promotion.

Key words: Alzheimer disease, exercise therapy, cognition, comprehensive geriatric assessment, agitation behaviour, mood state