Abstract: Objective To investigate the correlation between serum Periostin level and left ventricular hypertrophy (LVH) in patients with chronic kidney disease (CKD). Methods A total of 136 CKD patients were selected. According to the estimated glomerular filtration rate (eGFR), the patients were divided into 3 groups: A (stage Ⅰ-Ⅱ, n=56), B (stage Ⅲ, n=38) and C (stage Ⅳ-Ⅴ, n=42). In addition, 30 healthy individuals who had physical examinations during the same period were selected as the control group. The difference of serum Periostin levels and general data in patients with different stages of CKD were compared. Pearson method was used to analyze the correlation between serum Periosti and other indexes in patients with CKD. According to whether CKD patients were combined with LVH, they were divided into the LVH group (n= 32) and the non-LVH group (n=104). The general data and serum levels of Periostin were compared between the two groups. The risk factors of CKD patients with LVH were analyzed by Logistic regression. Results (1) Systolic blood pressure, diastolic blood pressure, homocysteine (HCY), creatinine (SCr), urea nitrogen (BUN), left ventricular mass index (LVMI) and Periostin increased gradually in group A, B and C, and there were significant differences between any two of indicators (P＜ 0.05). (2) The serum levels of Periodin in CKD patients were positively correlated with systolic blood pressure, HCY, SCr, BUN and LVMI (P＜0.05). (3) The systolic blood pressure, diastolic blood pressure, HCY, SCr, BUN, LVMI and Periodin were significantly higher in the LVH group than those of the non-LVH group (P＜0.05). (4) Logistic regression analysis showed that the increased systolic blood pressure (OR=1.793, 95%CI: 1.018-3.160), HCY (OR=1.978, 95%CI: 1.118-3.499) and Periotin (OR=2.119, 95%CI: 1.332-3.372) were independent risk factors for CKD patients with LVH (P＜0.05). Conclusion The serum level of Periostin is abnormally high in CKD patients, and its expression level is closely related to left ventricular hypertrophy.

Key words: hypertrophy, left ventricular, glomerular filtration rate, chronic kidney disease, Periostin