Abstract: Abstract: Objective To summarize the treatment experiences in patients with cardiac surgery- associated acute kidney injury (CSA- AKI). Methods The clinical data of 9 patients with acute renal injury after orthotopic heart transplantation in our hospital from January 2009 to July 2016 were retrospectively analyzed. Three patients were required the high- dose diuretics (furosemide, >80 mg/d) and six patients were received continuous renal replacement therapy (CRRT). The levels of serum creatinine (Cr) and estimated glomerular filtration rate (eGFR) were compared before and after heart transplantation and after the treatment of AKI. The quality of life was observed in patients in perioperative period. Results After the treatment of diuretics or CRRT, patients showed renal function recovery with significant decreased Cr levels and increased eGFR compared with the postoperation. The patients with diuretic therapy revealed a better eGFR recovery than those with CRRT. Conclusion CSA- AKI should be based on the severity of disease, and comprehensive treatment should be taken to reduce renal damage.

Key words: heart transplantation, intraoperative period, kidney failure, acute, perioperative period, diuretics, glomerular filtration rate, continuous renal replacement therapy, creatinine