Abstract: Mild traumatic brain injury (mTBI), known as brain concussion, accounts for most of traumatic brain injury (TBI) cases. Neurodegeneration could be observed in brains of some mTBI patients in the long term after injury. The underlying pathological mechanism has not been fully elucidated, which seriously affects the exploration and development of treatment strategies. On the basis of reviewing the procedure of pathological development in injured brain after moderate and severe TBI, this paper contrastively discussed the reported characteristics of pathological changes after repetitive mTBI. In addition, we also summarized the new progress in its therapeutic strategies, which will provide a basis for exploring longterm and comprehensive therapeutic strategies in the future.

Key words: craniocerebral trauma, neurodegenerative diseases, repetitive mild traumatic brain injury, neurological dysfunction, neurodegeneration