Abstract: Objective　To explore the relationship between single nucleotide polymorphism (SNP) of pharmacokinetic genes and postoperative disease-free survival in patients with esophageal squamous cell carcinoma, and to evaluate the prognosis of patients undergoing surgery. Methods　Seventy-seven patients with esophageal squamous cell carcinoma were selected in the study. Seven SNPs-ATP binding cassette subfamily B member 1 (ABCB1) rs1045642, rs2032582, rs3213619, ATP binding cassette subfamily G member 2 (ABCG2) rs2231137, rs2231142, ATP binding cassette subfamily C member 1 (ABCC1) rs246221 and ATP binding cassette subfamily C member 2 (ABCC2) rs3740066 were sequenced, and the relationship between genetic variation and disease-free survival was evaluated by Cox regression model. Semi-Bayesian shrinkage method was applied to correct for multiple comparison and small sample size issues. Results　With the dominant genetic model, the minor allele of ABCC2 rs3740066 was significantly associated with shorter disease-free survival [crude hazard ratio (cHR) 95%CI= 4.623 (1.111-19.241), P=0.035, adjusted hazard ratio (aHR) 95% CI= 4.290 (1.010-18.215), P=0.048]. Conclusion　The SNP rs3740066 of pharmacokinetic gene ABCC2 is associated with postoperative disease-free survival in patients with esophageal squamous cell carcinoma.

Key words: esophageal neoplasms, carcinoma, squamous cell, polymorphism, single nucleotide, disease-free survival, ATP binding cassette transporter, sub-family C, member 2