The effect of permissibility hypercapnia on postoperative delirium in elderly patients undergoing thoracoscopic radical surgery of esophageal cancer

doi:10.11958/20220699

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R614.2

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References 16

[1]	WANG L, YANG L, YANG J, et al. Effects of permissive hypercapnia on laparoscopic surgery for rectal carcinoma[J]. Gastroenterol Res Pract, 2019, 2019:3903451. doi:10.1155/2019/3903451.
[2]	HICKLING K G, HENDERSON S J, JACKSON R. Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome[J]. Intensive Care Med, 1990, 16(6):372-377. doi:10.1007/BF01735174.
[3]	NI C, XU T, LI N, et al. Cerebral oxygen saturation after multiple perioperative influential factors predicts the occurrence of postoperative cognitive dysfunction[J]. BMC Anesthesiol, 2015, 15:156. doi:10.1186/s12871-015-0117-6.
[4]	Cerebral Oxygenation and Neurological Outcomes Following Critical Illness CONFOCAL Research Group, Canadian Critical Care Trials Group, WOOD M D, et al. Low brain tissue oxygenation contributes to the development of delirium in critically ill patients:A prospective observational study[J]. J Crit Care, 2017, 41:289-295. doi:10.1016/j.jcrc.2017.06.009.
[5]	JIANG X, CHEN D, LOU Y, et al. Risk factors for postoperative delirium after spine surgery in middle- and old-aged patients[J]. Aging Clin Exp Res, 2017, 29(5):1039-1044. doi:10.1007/s40520-016-0640-4.
[6]	ALDECOA C, BETTELLI G, BILOTTA F, et al. European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium[J]. Eur J Anaesthesiol, 2017, 34(4):192-214.doi:10.1097/EJA.0000000000000594.
[7]	JONES R N, MARCANTONIO E R, SACZYNSKI J S, et al. Preoperative cognitive performance dominates risk for delirium among older adults[J]. J Geriatr Psychiatry Neurol, 2016, 29(6):320-327. doi:10.1177/0891988716666380.
[8]	DEINER S, CHU I, MAHANIAN M, et al. Prone position is associated with mild cerebral oxygen desaturation in elderly surgical patients[J]. PLoS One, 2014, 9(9):e106387. doi:10.1371/journal.pone.0106387.
[9]	MAHESHWARI K, AHUJA S, KHANNA A K, et al. Association between perioperative hypotension and delirium in postoperative critically ill patients:A retrospective cohort analysis[J]. Anesth Analg, 2020, 130(3):636-643. doi:10.1213/ANE.0000000000004517.
[10]	INOUYE S K. Delirium in older persons[J]. N Engl J Med, 2006, 354(11):1157-1165. doi:10.1056/NEJMra052321.
[11]	WANG Y, SHEN X. Postoperative delirium in the elderly:the potential neuropathogenesis[J]. Aging Clin Exp Res, 2018, 30(11):1287-1295. doi:10.1007/s40520-018-1008-8.
[12]	PAGE V J, CASARIN A, ELY E W, et al. Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation (MoDUS):a randomised,double-blind,placebo-controlled trial[J]. Lancet Respir Med, 2017, 5(9):727-737. doi:10.1016/S2213-2600(17)30234-5.
[13]	TRZEPACZ P T. Anticholinergic model for delirium[J]. Semin Clin Neuropsychiatry, 1996, 1(4):294-303. doi:10.1053/SCNP00100294.
[14]	YOSHITANI K, KUWAJIMA K, IRIE T, et al. Clinical validity of cerebral oxygen saturation measured by time-resolved spectroscopy during carotid endarterectomy[J]. J Neurosurg Anesthesiol, 2013, 25(3):248-253. doi:10.1097/ANA.0b013e31827ee0cf.
[15]	NNOROM C C, DAVIS C, FEDINEC A L, et al. Contributions of KATP and KCa channels to cerebral arteriolar dilation to hypercapnia in neonatal brain[J]. Physiol Rep, 2014, 2(8):e12127. doi:10.14814/phy2.12127.
[16]	PARK C G, JUNG W S, PARK H Y, et al. Comparison of the effects of normocapnia and mild hypercapnia on the optic nerve sheath diameter and regional cerebral oxygen saturation in patients undergoing gynecological laparoscopy with total intravenous anesthesia[J]. J Clin Med, 2021, 10(20):4707. doi:10.3390/jcm10204707.

组别	性别（女/男）	年龄（岁）	BMI （kg/m²）	ASA分级（Ⅱ/Ⅲ）	MMSE评分（分）
N组	10/36	70.4±4.1	23.0±2.5	32/14	27.6±1.5
H组	13/33	70.0±3.3	22.4±1.8	31/15	27.8±1.5
t或χ²	0.522	0.615	1.365	0.050	0.825

组别	性别（女/男）	年龄（岁）	BMI （kg/m²）	ASA分级（Ⅱ/Ⅲ）	MMSE评分（分）
N组	10/36	70.4±4.1	23.0±2.5	32/14	27.6±1.5
H组	13/33	70.0±3.3	22.4±1.8	31/15	27.8±1.5
t或χ²	0.522	0.615	1.365	0.050	0.825

时点	组别	MAP（mmHg）	HR（次/min）	rSO₂
T₀	N组 H组	93.6±6.5 92.3±7.2	69.3±8.8 69.0±8.1	0.69±0.03 0.68±0.03
T₁	N组 H组	83.0±6.8^a 82.3±7.7^a	67.7±6.9^a 67.7±7.3^a	0.65±0.03^a 0.64±0.03^a
T₂	N组 H组	82.2±6.4^a 85.2±6.1^aA	65.0±6.7^a 66.8±6.4^a	0.65±0.02^a 0.67±0.02^aA
T₃	N组 H组	81.1±6.2^a 85.6±8.3^aA	62.8±6.7^a 65.3±7.3^a	0.63±0.02^a 0.66±0.03^aA
T₄	N组 H组	79.0±6.8^a 85.0±7.5^aA	62.1±6.2^a 64.2±7.8^a	0.62±0.03^a 0.65±0.03^aA

时点	组别	MAP（mmHg）	HR（次/min）	rSO₂
T₀	N组 H组	93.6±6.5 92.3±7.2	69.3±8.8 69.0±8.1	0.69±0.03 0.68±0.03
T₁	N组 H组	83.0±6.8^a 82.3±7.7^a	67.7±6.9^a 67.7±7.3^a	0.65±0.03^a 0.64±0.03^a
T₂	N组 H组	82.2±6.4^a 85.2±6.1^aA	65.0±6.7^a 66.8±6.4^a	0.65±0.02^a 0.67±0.02^aA
T₃	N组 H组	81.1±6.2^a 85.6±8.3^aA	62.8±6.7^a 65.3±7.3^a	0.63±0.02^a 0.66±0.03^aA
T₄	N组 H组	79.0±6.8^a 85.0±7.5^aA	62.1±6.2^a 64.2±7.8^a	0.62±0.03^a 0.65±0.03^aA

组别	输液量（mL）	尿量（mL）	出血量（mL）	麻黄素（mg）
N组	2 451.1±508.1	747.8±287.3	186.6±102.0	5.8±3.2
H组	2 484.8±454.5	753.3±253.9	175.2±100.8	4.0±2.5
t	0.335	0.096	0.540	3.014^＊＊

The effect of permissibility hypercapnia on postoperative delirium in elderly patients undergoing thoracoscopic radical surgery of esophageal cancer

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组别	术后1 d	术后2 d	术后3 d
N组	2.8±1.0	2.3±0.9^a	1.9±0.8^a
H组	2.8±0.9	2.3±0.9^a	1.9±0.8^a

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