Abstract: Objective　To investigate the serum levels of low density lipoprotein receptor (LDLR) and dynamin 2 (DNM2) in elderly patients with chronic heart failure (CHF) and their clinical significance. Methods　A total of 123 CHF patients (the CHF group) and 120 healthy people (the control group) were selected. According to New York Heart Association (NYHA) classification, there were 42 cases of grade Ⅱ, 61 cases of grade Ⅲ and 20 cases of grade Ⅳ in the CHF group. The serum levels of LDLR, DNM2 and cardiac function indexes were compared between the CHF group and the control group. Pearson correlation analysis was performed to analyze the correlation between LDLR, DNM2, left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF) and N-terminal B-type brain natriuretic peptide precursor (NT-probNP). After six months of follow-up, CHF patients were divided into the good prognosis group (98 cases) and the poor prognosis group (25 cases). The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of LDLR and DNM2 for CHF with poor prognosis. Results　Compared with the control group, the serum levels of LDLR, DNM2 and LVEF decreased in patients with different NYHA grades than those of the control group, while the levels of LVEDD and NT-proBNP were higher than those of the control group (P＜0.05). With the increase of NYHA classification, serum levels of LDLR, DNM2 and LVEF gradually decreased in CHF patients, while LVEDD and NT-proBNP levels gradually increased (P＜0.05). Serum levels of LDLR and DNM2 were positively correlated with LVEF in CHF patients, but negatively correlated with LVEDD and NT-proBNP (P＜0.01). The serum levels of LDLR and DNM2 were lower in the poor prognosis group than those in the good prognosis group (P＜0.05). The ROC curve showed that the area under the curve of LDLR combined with DNM2 in the diagnosis of poor prognosis in CHF patients was significantly higher [0.858 (95%CI: 0.751-0.965)] than that of LDLR [0.793 (95%CI: 0.668-0.919)] and DNM2 [0.777 (95%CI: 0.669-0.884)], the sensitivity and specificity were improved. Conclusion　Serum levels of LDLR and DNM2 are decreased with the the increase of NYHA classification in CHF patients, which can reflect cardiac function. The combination of the two indicators is helpful to evaluate the prognosis of patients with CHF.

Key words: heart failure, receptors, LDL, dynamin 2, cardiac function grading