Abstract: Cardiovascular disease, as a disease with high mortality and disability rates, is a constant threat to human
health. In recent years, with the continuous development of research, it has been reported that intestinal flora and its
metabolites are also involved in the occurrence and development of cardiovascular diseases (including atherosclerosis, heart
failure and hypertension). By improving the composition of intestinal flora and its metabolites can improve the progression of
cardiovascular diseases. This treatment has become a new target for the treatment of cardiovascular diseases. In this paper,
the composition of intestinal flora, the role of intestinal flora metabolites and the relationship between intestinal flora and its
metabolites and atherosclerosis, heart failure, hypertension and other diseases were reviewed.

Key words: gastrointestinal microbiome, coronary artery disease, heart failure, fatty acids, volatile, review