Changes of serum H2S in patients with osteoporosis and its clinical significance

doi:10.11958/20212020

Abstract

Abstract:

Objective To investigate changes and clinical significance of serum hydrogen sulfide (H₂S) in patients with osteoporosis. Methods A total of 128 patients with osteoporosis admitted to our hospital were used as the osteoporosis group, and another 110 patients with low back pain in our hospital during the same period were selected as the control group. The Asian Osteoporosis Self-screening Tool (OSTA) was used to screen for osteoporosis risk by measuring bone mineral density in the lumbar spine (L_1-4) and bilateral femoral neck with dual energy X-ray spectrometer. Five mL of fasting venous blood was collected from all patients after admission. Serum H₂S, alkaline phosphatase (ALP), bone specific alkaline phosphatase (BALP), serum phosphorus, serum calcium, parathyroid hormone (iPTH), CTX, N-terminal propeptide of type 1 procollagen (P1NP), cross-linking C-terminal peptide of urinary 1 collagen (P1CP) and special sequence of carboxy-terminal peptide of type Ⅰ collagen (β-CTX) were detected. Pearson correlation analysis was conducted to analyze the correlation between serum H₂S and bone metabolic markers in patients with osteoporosis. Results Compared with the control group, the bone mineral density of lumbar vertebra and femoral neck decreased, the serum H₂S concentration decreased, the serum ALP, BALP, serum osteocalcin, P1NP, P1CP and iPTH concentration decreased, and the β-CTX level increased in the osteoporosis group (P<0.05). Serum H₂S was positively correlated with ALP, BALP, serum osteocalcin, P1NP, P1CP and iPTH in patients with osteoporosis, but negatively correlated with β-CTX (P<0.05). Conclusion The serum level of H₂S is significantly decreased in patients with osteoporosis. The detection of H₂S is helpful to evaluate the bone metabolism in patients.

Key words: osteoporosis, hydrogen sulfide, bone metabolism, bone mineral density

CLC Number:

R681.4

Figures/Tables 2

References 19

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组别	n	年龄（岁）	性别（男/女）	BMI （kg/m²）	腰椎骨密度（g/cm²）	股骨颈骨密度（g/cm²）	血钙（mmol/L）	血磷（mmol/L）	OSTA 指数	血清H₂S （μmol/L）
对照组	110	53.8±11.2	49/61	23.73±2.12	1.41±0.56	1.02±0.27	2.29±0.12	1.34±0.27	1.8±0.5	42.43±5.49
骨质疏松组	128	54.6±9.78	54/74	23.75±2.73	1.05±0.42	0.85±0.14	2.30±0.14	1.36±0.35	-3.8±1.9	33.60±6.13
χ²或t		0.591	0.134	0.065	5.655^＊＊	6.218^＊＊	0.587	0.487	30.018^＊＊	11.730^＊＊

组别	n	年龄（岁）	性别（男/女）	BMI （kg/m²）	腰椎骨密度（g/cm²）	股骨颈骨密度（g/cm²）	血钙（mmol/L）	血磷（mmol/L）	OSTA 指数	血清H₂S （μmol/L）
对照组	110	53.8±11.2	49/61	23.73±2.12	1.41±0.56	1.02±0.27	2.29±0.12	1.34±0.27	1.8±0.5	42.43±5.49
骨质疏松组	128	54.6±9.78	54/74	23.75±2.73	1.05±0.42	0.85±0.14	2.30±0.14	1.36±0.35	-3.8±1.9	33.60±6.13
χ²或t		0.591	0.134	0.065	5.655^＊＊	6.218^＊＊	0.587	0.487	30.018^＊＊	11.730^＊＊

组别	n	ALP（U/L）	BALP（U/L）	骨钙素（μg/L）	P1NP（μg/L）	P1CP（μg/L）	iPTH（μg/L）	β-CTX（μg/L）
对照组	110	49.6±7.1	34.2±5.7	16.28±2.41	231.4±52.4	78.4±12.4	45.9±6.7	0.32±0.10
骨质疏松组	128	34.5±5.2	22.7±3.8	12.14±1.87	207.5±42.3	42.8±5.4	34.1±4.2	0.36±0.14
t		18.882^＊＊	18.534^＊＊	14.905^＊＊	3.892^＊＊	29.406^＊＊	16.508^＊＊	2.498^＊

组别	n	ALP（U/L）	BALP（U/L）	骨钙素（μg/L）	P1NP（μg/L）	P1CP（μg/L）	iPTH（μg/L）	β-CTX（μg/L）
对照组	110	49.6±7.1	34.2±5.7	16.28±2.41	231.4±52.4	78.4±12.4	45.9±6.7	0.32±0.10
骨质疏松组	128	34.5±5.2	22.7±3.8	12.14±1.87	207.5±42.3	42.8±5.4	34.1±4.2	0.36±0.14
t		18.882^＊＊	18.534^＊＊	14.905^＊＊	3.892^＊＊	29.406^＊＊	16.508^＊＊	2.498^＊

Changes of serum H₂S in patients with osteoporosis and its clinical significance

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