Tianjin Medical Journal ›› 2022, Vol. 50 ›› Issue (10): 1110-1114.doi: 10.11958/20220531

• Review • Previous Articles     Next Articles

The research progress and function of SARS-CoV-2 accessory protein ORF8

FU Ya'nan(), ZENG Feng, RAO Jingjing, HUANG Yanping, LIU Zhixin, LIU Long()   

  1. School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China
  • Received:2022-04-12 Revised:2022-05-27 Published:2022-10-15 Online:2022-10-20
  • Contact: LIU Long E-mail:3064909472@qq.com;liulong2015@outlook.com

Abstract:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a genome similar to that of the SARS-CoV, which has been circulating since 2002 and encodes multiple viral proteins. The accessory protein ORF8 has low sequence homology with SARS-CoV ORF8, and has characteristics of rapid evolution and mutation. It has functions of inhibiting type I interferon and down-regulating the expression of major histocompatibility complex I (MHC I). This paper reviews the structure and function of accessory protein ORF8 and the diagnostic and therapeutic prospects for COVID-19.

Key words: SARS virus, immune escape, mutation, evolution, molecular, SARS-CoV-2, ORF8

CLC Number: