The research progress and function of SARS-CoV-2 accessory protein ORF8

doi:10.11958/20220531

Abstract

Abstract:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a genome similar to that of the SARS-CoV, which has been circulating since 2002 and encodes multiple viral proteins. The accessory protein ORF8 has low sequence homology with SARS-CoV ORF8, and has characteristics of rapid evolution and mutation. It has functions of inhibiting type I interferon and down-regulating the expression of major histocompatibility complex I (MHC I). This paper reviews the structure and function of accessory protein ORF8 and the diagnostic and therapeutic prospects for COVID-19.

Key words: SARS virus, immune escape, mutation, evolution, molecular, SARS-CoV-2, ORF8

CLC Number:

R373.1

Figures/Tables 1

References 33

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