Eucommia ulmoides leaves total flavonoids participate in the repair of neural function in rats with cerebral hemorrhage through RhoA/ROCK signaling pathway

doi:10.11958/20221033

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R285.5

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References 23

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组别	脑组织含水量	脑血肿体积百分比
假手术组	76.33±0.61	0
模型组	81.09±0.94^a	25.31±1.06^a
杜仲叶总黄酮组	78.04±0.72^ab	10.36±0.72^ab
RhoA抑制剂组	78.38±0.74^ab	10.49±0.79^ab
RhoA激动剂组	84.90±1.02^abcd	31.00±1.37^abcd
杜仲叶总黄酮+RhoA激动剂组	80.97±0.90^acde	25.28±0.95^acde
F	79.488^＊＊	1 011.827^＊＊

组别	脑组织含水量	脑血肿体积百分比
假手术组	76.33±0.61	0
模型组	81.09±0.94^a	25.31±1.06^a
杜仲叶总黄酮组	78.04±0.72^ab	10.36±0.72^ab
RhoA抑制剂组	78.38±0.74^ab	10.49±0.79^ab
RhoA激动剂组	84.90±1.02^abcd	31.00±1.37^abcd
杜仲叶总黄酮+RhoA激动剂组	80.97±0.90^acde	25.28±0.95^acde
F	79.488^＊＊	1 011.827^＊＊

组别	凋亡率（%）	OD值
假手术组	0.51±0.03	2.98±0.23
模型组	20.75±1.07^a	0.75±0.07^a
杜仲叶总黄酮组	6.41±0.63^ab	2.11±0.18^ab
RhoA抑制剂组	6.49±0.64^ab	2.09±0.19^ab
RhoA激动剂组	29.22±1.55^abcd	0.22±0.02^abcd
杜仲叶总黄酮+RhoA激动剂组	20.50±1.00^acde	0.70±0.07^acde
F	1 103.363^＊＊	419.289^＊＊

组别	凋亡率（%）	OD值
假手术组	0.51±0.03	2.98±0.23
模型组	20.75±1.07^a	0.75±0.07^a
杜仲叶总黄酮组	6.41±0.63^ab	2.11±0.18^ab
RhoA抑制剂组	6.49±0.64^ab	2.09±0.19^ab
RhoA激动剂组	29.22±1.55^abcd	0.22±0.02^abcd
杜仲叶总黄酮+RhoA激动剂组	20.50±1.00^acde	0.70±0.07^acde
F	1 103.363^＊＊	419.289^＊＊

组别	RhoA/ β-actin	ROCK/ β-actin	F-actin/ β-actin	p-cofilin/ cofilin
假手术组	0.83±0.08	0.92±0.09	1.01±0.10	1.09±0.09
模型组	1.31±0.20^a	1.35±0.22^a	0.47±0.03^a	0.50±0.06^a
杜仲叶总黄酮组	1.02±0.14^ab	1.04±0.15^ab	0.83±0.08^ab	0.95±0.10^ab
RhoA抑制剂组	1.03±0.13^ab	1.03±0.16^ab	0.80±0.08^ab	0.92±0.09^ab
RhoA激动剂组	1.85±0.26^abcd	2.02±0.29^abcd	0.16±0.02^abcd	0.25±0.02^abcd
杜仲叶总黄酮+ RhoA激动剂组	1.33±0.21^acde	1.40±0.24^acde	0.49±0.03^acde	0.48±0.05^acde
F	31.813^＊＊	31.787^＊＊	184.064^＊＊	162.608^＊＊

Eucommia ulmoides leaves total flavonoids participate in the repair of neural function in rats with cerebral hemorrhage through RhoA/ROCK signaling pathway

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组别	NGF	NT3	PSD-95	SYP
假手术组	1.17±0.16	1.15±0.08	1.19±0.10	1.12±0.08
模型组	0.40±0.03^a	0.38±0.04^a	0.50±0.06^a	0.47±0.03^a
杜仲叶总黄酮组	0.81±0.07^ab	0.86±0.08^ab	0.99±0.09^ab	1.00±0.08^ab
RhoA抑制剂组	0.79±0.08^ab	0.83±0.07^ab	0.94±0.08^ab	0.99±0.09^ab
RhoA激动剂组	0.20±0.02^abcd	0.14±0.01^abcd	0.17±0.01^abcd	0.18±0.01^abcd
杜仲叶总黄酮+ RhoA激动剂组	0.39±0.03^acde	0.43±0.03^acde	0.51±0.05^acde	0.44±0.05^acde
F	158.347^＊＊	333.817^＊＊	230.504^＊＊	291.698^＊＊

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