Advances in multi-omics research of follicular fluid based on the decline in oocyte quality

doi:10.11958/20253362

Abstract

Abstract:

In recent years, rapid advances in multi-omics technologies have substantially promoted metabolomic, proteomic and transcriptomic investigations of follicular fluid (FF), providing novel insights into the molecular mechanism underlying oocyte quality deterioration. During the process of ovarian function decline and reproductive aging, hormone levels, energy metabolism and lipid metabolism characteristics in FF have undergone significant changes. It is accompanied by the imbalance in inflammatory and immune-related pathways. A variety of key proteins in FF not only participate in ovulation, tissue remodeling and signal transduction, but are also closely related to the quality of oocytes and the outcome of embryonic development. This review systematically summarizes recent progress in FF-based multi-omics research and discusses its potential applications in oocyte quality assessment and precision decision-making in assisted reproductive technologies.

Key words: follicular fluid, oocytes, metabolomics, proteomics, transcriptome, reproductive techniques, assisted

CLC Number:

R711.75

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