Research progress on the mechanism of SIRT1 in regulating podocyte injury-induced proteinuria

doi:10.11958/20253032

Abstract

Abstract:

Proteinuria is an important clinical indicator for the early diagnosis of kidney disease and disease progression, and its occurrence is related to podocyte injury. Sirtuin 1 ( SIRT1 ) is a highly conserved multifunctional protein that acts as a nicotinamide adenine dinucleotide-dependent deacetylase and affects a variety of biological processes by regulating the deacetylation process of transcription factors. It can also participate in signal transduction by virtue of its non-enzymatic activity mechanism, which together constitute the molecular basis for its regulation of podocyte homeostasis. Relevant studies have shown that SIRT1 is closely related to podocyte injury. It regulates macrophage function, autophagy process, lipid metabolism, oxidative stress and epithelial-mesenchymal transition (EMT) process, and maintains mitochondrial homeostasis, thereby protecting podocytes, reducing proteinuria and delaying the progression of renal injury. Here is to make a preliminary review of the research on the related mechanisms in recent years, in order to provide reference for the related clinical and basic research. This article reviews the mechanism of SIRT1 regulating podocyte injury-induced proteinuria, in order to provide reference for further mechanism research and wider clinical application.

Key words: sirtuin 1, podocytes, proteinuria

CLC Number:

R692.6

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