Abstract: [Abstract]  Objective   To assess the effect of continuous renal replacement therapy (CRRT) on severe acute pancreatitis (SAP)．Methods   According to the collaborative search strategy，MEDLINE(1966-2013.9), OVID(1963-2013.9), Chinese Wanfang database(1996-2013.9）,CNKI（1979-2013.9）, the clinical control test database of Cochrane Library and were searched．Related literature，whether Published or not and meeting summary included，were searched by hand．Quality assessment and data extraction were conducted by two independent investigators．Meta-analysis was conducted by RevMan 5.0.Results   A total of 15 reports were identified which met the inclusion criteria，including 652 patients．Compared with control group ,the serum amylase decreased in CRRT group [WMD =-140.76，95%CI（-212.42～-69.11），P=0.0001], inflammatory mediators removed effectively and APACHEⅡ score also decreased in CRRT group [WMD=-3.09，95%CI（-4.37～-1.45，P=0.0002]. The overall survival rate was significantly higher in CRRT group than that in control group[RR=1.35，95%CI（1.19～1.52），P<0.00001].Conclusion   Continuous renal replacement therapy could effectively improve the prognosis of patients with severe acute pancreatitis.

Key words: pancreatitis, renal replacement therapy, prognosis, Meta-analysis, amylases, C-reactive protein, severe acute pancreatitis, 连续性肾脏替代治疗