Abstract: Abstract Objective：To investigate the changes of the levels of high sensitivity reactive protein C (hs-CRP)，white blood cell(WBC) and fibrinogen(FIB) in Nonalcoholic Fatty Liver Disease (NAFLD) with type 2 Diabetes. Methods： Four hundred and thirty patients with type 2 diabetes were divided into NAFLD group and non-NAFLD group according to with or without NAFLD. The changes of the levels of hs-CRP，WBC and FIB in the two groups and the relationship between their levels and NAFLD were analyzed. Results：Compared to non-NAFLD group，the levels of hs-CRP，WBC，FIB in NAFLD group were increased obviously（3.86±4.09 vs2.41±3.48; 6.84±1.66vs6.42±1.70; 3.65±0.76vs3.42±0.81,P<0.05）.Using univariate logistic regression analysis it was found that NAFLD had a positive correlation with hs-CRP，WBC，FIB（OR=1.098，95%CI：1.038～1.163；OR=1.351, 95%CI：1.006～1.317; OR=1.395, 95%CI：1.063～1.831），In a multiple logistic regression analysis，after adjusting the age，gender，the ascend duration of diabetes，smoking , blood pressure, lipid and body mass index(BMI)，the levels of hs-CRP still had a predominant relation with NAFLD(OR=1.197，95%CI：1.098～1.305). Conclusion： Subclinial inflammatory factors, especially the levels of hs-CRP, are closely related with NAFLD.Changing the inflammatory condition of the patients with type 2 diabetes can be used for prevention and cure for NAFLD.

Key words: nonalcoholic fatty liver disease, diabetes mellitus, type 2, insulin resistence, white blood cell, hypersensitivity reactive protein C, fibrinogen