Abstract:

[Abstract]   Objective   To investigate the distribution of pathogens in adult patients with community-acquired pneumonia (CAP) in Tangshan area.   Methods   The clinical data of530hospitalized patients with CAP were retrospectively collected in department of respiratory medicine from6hospitals in Tangshan area from October2011to September2012. The sputum samples were isolated and cultured.  Results   A total of 195 strains were isolated from530patients with CAP. The most common types of pathogens includedKlebsiella pneumoniae(64strains,12.08%),Streptococcus pneumoniae(24strains,4.53%) andBauman Acinetobacter(19strain,3.58%). The detective rates ofKlebsiella pneumoniaeandPseudomonas aeruginosawere significantly higher in patients with basic diseases than those of patients without basic diseases (P<0.05). The detective rates ofKlebsiella pneumoniaeandStreptococcus pneumoniaewere significantly higher in patients not taking antibiotics than those of patients taking antibiotics (P<0.05). The detective rates of Klebsiella pneumoniae, Bauman AcinetobacterandPseudomonas aeruginosa were significantly higher in the age group≥60years than those in the age group <60years (P<0.05). The detective rates of Klebsiella pneumoniaewere significantly increased with increased levels of PORT (P<0.05). There were no significant differences in the detective rates of pathogens between different regions and different seasons (P>0.05).  Conclusion   The gram-negative bacterial pathogens were the majority isolated from patients with CAP in Tangshan area. And Klebsiella pneumoniaewas the primary bacteria. Patients with serious illness, above60years old, without antibiotic treatment before hospitalization, with basic diseases and above PORT Ⅲ levels should be given treatment of anti-gram-negative bacteria.

Key words: pneumonia, opportunistic infections, epidemiologic studies, adult, community acquired pneumonia