Abstract: [Abstract] Objective   To investigate the levels of ox-LDL in patients with cerebral infarction，and to evaluate the effect of the supplement therapy with probucol on the plasma concentrations of ox-LDL. Methods    ox-LDL, NO and eNOS concentrations were measured in subjects of cerebral infarction normotensive group, cerebral infarction with hypertension group and health control group, each of which had 60 cases. Patients in acute cerebral infarction normotensive group and hypertension group were randomized to divided into intervention group and nonintervention group respectively. Patients in the intervention group had been treated with probucol for 12 weeks. Then ox-LDL, eNOS, NO were measured after 2 weeks and 12 weeks of supplementation. Results  The levels of ox-LDL in plasma were raised significantly in patients with acute cerebral infarction (P<0.05), as well as the levels of eNOS and NO in serum were reduced obviously (P<0.05). The ADMA and Hcy levels in cerebral infarction hypertension group were higher than those in cerebral infarction normotension group (P<0.05), while the eNOS and NO levels were lower (P<0.05). With supplementation of probucol for 2 weeks and 12 weeks, the level of ox-LDL were decreased significantly (P<0.05). Conclusion  The present study demonstrated that ox-LDL which inhibited eNOS, reduced NO production, eading to endothelial dysfunction, was regarded as a risk fator of cerebral infarction. With supplementation of probucol, levels of ox-LDL were able to be decreased significantly, and sequential improvement of the endothelial function, which was propitious to anti-artherosclerosis. These findings provided a novel target for pharmacotherapy of cerebral infarction.

Key words: Probucol, brain infarction, hypertension, lipoproteins, LDL, nitric oxide synthase, nitric oxide, 氧化型低密度脂蛋白