Predictive value of serum total IgE, eosinophils, diamine oxidase and fractional exhaled nitric oxide in allergic rhinitis combined with bronchial asthma

doi:10.11958/20250328

Abstract

Abstract:

Objective To investigate the predictive value of serum total IgE, eosinophil (EOS) ratio, lactate dehydrogenase (LDH) and exhaled nitric oxide (FeNO) levels in allergic rhinitis (AR) complicated with bronchial asthma (BA). Methods A total of 127 children with AR were divided into the AR group (84 cases) and the AR+BA group (43 cases) based on the presence of BA. Another 55 healthy children were selected as the control group. General data, total IgE, EOS ratio, LDH and FeNO levels were compared between the three groups. The correlation between these indicators and duration of disease symptoms, nasal symptom scores were analyzed. Receiver operating characteristics (ROC) curve analysis was performed to evaluate the predictive value of these indicators for AR and AR+BA. Results Total IgE, EOS ratio, LDH and FeNO levels were significantly higher in the AR group and the AR+BA group than those in the control group (P<0.05). The total IgE, EOS ratio and FeNO levels were higher in the AR+BA group than those in the AR group (P<0.05). Correlation analysis showed that total IgE, EOS ratio and FeNO levels were positively correlated with the duration of disease symptoms and symptom scores in the AR group and the AR+BA group (P<0.05). In the AR group, LDH levels were positively correlated with the duration of disease symptoms and symptom scores (P<0.05), but in the AR+BA group, there was no significant correlation between the duration of BA symptoms and symptom scores (P>0.05). ROC curve analysis indicated that total IgE, FeNO, EOS ratio and LDH all had predictive values for both AR and AR+BA. The predictive value of total IgE for AR and AR+BA was higher (AUC=0.971 and 0.800). Combined detection of total IgE, EOS ratio, LDH and FeNO had the best predictive value for AR+BA (AUC=0.904). Conclusion Serum levels of total IgE, LDH, EOS ratio and FeNO can be served as effective indicators for predicting AR complicated with BA. Combined detection can improve the accuracy of prediction and provide a reference for early clinical identification and intervention in AR+BA.

Key words: rhinitis, allergic, asthma, total IgE, neosinophils, lactate dehydrogenase, exhaled nitric oxide

CLC Number:

R725.62，R765.21

Figures/Tables 7

References 19

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组别		n	年龄/岁	性别		BMI/（kg/m2）
组别		n	年龄/岁	男	女	BMI/（kg/m2）
对照组		55	7.0±2.5	32（58.2）	23（41.8）	17.5±2.9
AR组		84	7.2±2.8	53（63.1）	31（36.9）	17.8±3.2
AR+BA组		43	7.5±3.1	28（65.1）	15（34.9）	18.1±3.5
F或χ²			0.389	0.560		0.431
组别	家族过敏史			病程/月	本次症状持续时间/d	鼻部症状评分/分
组别	有		无	病程/月	本次症状持续时间/d	鼻部症状评分/分
对照组	18（32.7）		37（67.3）	-	-	2.3±1.2
AR组	63（75.0）^a		21（25.0）	16.5±4.8	8.3±1.6	6.5±1.8^a
AR+BA组	39（90.7）^ab		4（9.3）	18.2±5.6	12.5±4.3	7.2±2.1^ab
F、χ²或t	41.815^＊＊			12.579^＊＊	6.929^＊＊	129.481^＊＊

组别		n	年龄/岁	性别		BMI/（kg/m2）
组别		n	年龄/岁	男	女	BMI/（kg/m2）
对照组		55	7.0±2.5	32（58.2）	23（41.8）	17.5±2.9
AR组		84	7.2±2.8	53（63.1）	31（36.9）	17.8±3.2
AR+BA组		43	7.5±3.1	28（65.1）	15（34.9）	18.1±3.5
F或χ²			0.389	0.560		0.431
组别	家族过敏史			病程/月	本次症状持续时间/d	鼻部症状评分/分
组别	有		无	病程/月	本次症状持续时间/d	鼻部症状评分/分
对照组	18（32.7）		37（67.3）	-	-	2.3±1.2
AR组	63（75.0）^a		21（25.0）	16.5±4.8	8.3±1.6	6.5±1.8^a
AR+BA组	39（90.7）^ab		4（9.3）	18.2±5.6	12.5±4.3	7.2±2.1^ab
F、χ²或t	41.815^＊＊			12.579^＊＊	6.929^＊＊	129.481^＊＊

组别	n	总IgE/ （IU/mL）	EOS比例/ %	LDH/ （U/L）	FeNO/ （×10^-9）
对照组	55	76.7±36.8	2.58±1.40	188.48±32.95	15.09±7.12
AR组	84	274.7±98.8^a	4.94±2.04^a	310.57±43.50^a	33.60±9.52^a
AR+BA组	43	408.4±128.6^ab	6.44±3.25^ab	332.54±64.11^a	47.24±15.14^ab
F		157.560	37.957^＊＊	38.126^＊＊	116.250^＊＊

组别	n	总IgE/ （IU/mL）	EOS比例/ %	LDH/ （U/L）	FeNO/ （×10^-9）
对照组	55	76.7±36.8	2.58±1.40	188.48±32.95	15.09±7.12
AR组	84	274.7±98.8^a	4.94±2.04^a	310.57±43.50^a	33.60±9.52^a
AR+BA组	43	408.4±128.6^ab	6.44±3.25^ab	332.54±64.11^a	47.24±15.14^ab
F		157.560	37.957^＊＊	38.126^＊＊	116.250^＊＊

指标	AR组（n=84）		AR+BA组（n=43）
指标	症状持续时间	鼻部症状评分	症状持续时间	BA症状评分
总IgE	0.683^＊＊	0.725^＊＊	0.542^＊＊	0.618^＊＊
EOS比例	0.579^＊＊	0.632^＊＊	0.487^＊＊	0.553^＊＊
LDH	0.235^＊	0.287^＊	0.189	0.146
FeNO	0.712^＊＊	0.758^＊＊	0.635^＊＊	0.702^＊＊